Modern lifestyle has become a host for many abnormalities, especially with the gradual mutation, advancing maternal age and lack of proper healthcare infrastructure has depleted the live birth rate. Due to this, the priority of a number of governments in many countries is to take initiatives towards developing non-invasive solutions, launch a large number of screening programs and control the soaring level of genetic disorders with advanced technologies to meet the needs of the patients. Prenatal testing helps the expectant parent(s) in decision making, whether to continue or abort the pregnancy, as numerous cases related to Down syndrome, spina bifida, cleft palate, sickle cell anaemia, thalassemia, fragile X syndrome and Tay–Sachs disease among others have been reported, as a consequence of the mutant genes and an abnormal chromosomal structure.