Next-generation sequencing (NGS) has recently experienced a sharp increase in popularity and has become an essential diagnostic tool for many diseases. NGS is a revolutionary technological development in the field of life sciences that has paved the path for the development of numerous ground-breaking medical procedures aimed at addressing the primary global health issue.
Since Frederick Sanger devised a gene sequencing method in 1977, the analysis of genomic data has made significant strides. The development of DNA sequencing technologies has led to significant developments in several healthcare-related research fields, including diagnostics and customized medicine.
Additionally, advent of next-generation sequencing technology in genome sequencing procedures has led to significantly reduced costs and turnaround times of the procedures. NGS technology has huge potential that can enable the development of precision medicine and the understanding of the risk that a particular disease may pose to a person.
The conventional approach to library preparation had several drawbacks, including a high requirement for raw materials, low throughput, and low level of output quality. A genetic library can only be produced via manual processes, which also have other drawbacks, such as the need for expensive, time-consuming ingredients and specialized labor.
Therefore, NGS technology-based products such as NGS kits are in high demand in the healthcare sector.
Driven by improvements in sequencing technology that are beneficial to treatment and diagnostics, existence of a regulatory framework pertaining to sequencing, and government investments in sizable clinical and diagnostic laboratories to enable reliable NGS testing for a variety of infectious and chronic illnesses, the global NGS Kits market is expected to grow significantly.
According to the BIS Research report, in 2021, the global NGS kits market was valued at $4.6 billion, and it is expected to reach $26.05 billion by 2032, growing at a CAGR of 17.27% during the forecast period 2022-2032.
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The article goes into further detail about the NGS kits and their effective applications in the diagnostics and treatment of critical diseases.
What are NGS Kits?
NGS kits make the process of NGS library preparation for analysis faster and more effective. The significance of this step is that it converts DNA or RNA into a format that NGS sequencers can read. To do this, nucleic acids are broken up into smaller bits, and the sample is then given a set of distinctive barcodes for indexing. For preparations requiring high throughput, this is crucial. Now, the major use of next-generation sequencing (NGS) technology is to quickly extract the accurate and comprehensive sequence of required samples.
High resolution and accuracy, quick sequencing, throughput, and cost-effectiveness of genomic research are just some of the ways that NGS technology has improved. Research in biology and biomedicine has advanced significantly because of NGS technology advancement.
Additionally, advances in NGS technology now allow for faster whole-genome sequencing, RNA sequencing, and exome sequencing with a reduced run time. Advances in NGS technology are also promoting the growth of emerging industries based on sequencings, such as liquid biopsy, immunogenetics, precision medicine, and non-invasive prenatal testing.
How are NGS Kits Contributing to the Diagnostics and Treatments of Critical Diseases?
NGS has seen a rapid surge in popularity and has emerged as a crucial diagnostic tool for many diseases. A few of these applications are discussed below:
1. Oncology: Because of an accumulation of DNA mutations, cancer is a heterogeneous condition that worsens over time. New sequencing technologies have a profound impact on the diagnosis, treatment, and management of cancer. The hundreds of cancer genomes that have been read by next-generation sequencing give a road map for the ordinary human genome as well as a landscape of mutations in cancer genomes covering numerous cancer types.
Individualized cancer treatment has recently advanced thanks to the use of NGS kits in clinical oncology. The most appropriate targeted therapy can be determined genetically using NGS kits, which are used to identify unique and unusual cancer mutations, identify family members who also have cancer mutations, and locate novel and uncommon cancer mutations.
Among the many advantages of NGS technology over conventional sequencing is its capacity to completely sequence all varieties of mutations for numerous genes (hundreds to thousands) in a single test at a very reasonable cost. Due to technological advancements and the development of novel sequencing techniques over the past ten years, NGS has become increasingly utilized in cancer genomics research.
2. Rare Diseases: According to a research paper published in Springer in January 2021, one in fifteen people worldwide are estimated to have a rare condition. Since rare diseases are frequently seen in clinical practice, it might be challenging to make a prompt diagnosis.
The development of fresh approaches based on NGS technology allows for the successful diagnosis of genetically varied disorders even when the clinical diagnostic hypothesis is unclear.
However, there are significant differences in how advanced technology is used between hospitals and health systems. NGS might be systematically integrated into healthcare systems, which could significantly improve patients' access to diagnostics for rare diseases and reduce the requirement for cross-border collaboration on the side of national healthcare systems. With its rapid, high-throughput, and affordable techniques, NGS changed the area of genetic disease diagnostics.
3. Genetic Disorders: Birth defects, which are characterized as structural and functional abnormalities present at birth, are increasingly to blame for prenatal, neonatal, infant, and child mortality in developing countries. This is because the prevalence of infectious and nutritional reasons has declined as a result of universal vaccination, avoidance of respiratory and diarrheal disorders, and improvements in healthcare.
Genetic disorders and other birth defects can cause significant mortality, decreased productivity and quality of life, social shame, and financial hardship, especially in countries with few resources. Therefore, prevention is highly valued across the board. All facets of molecular research have been significantly impacted by next-generation sequencing (NGS) technologies, principally because they increase DNA sequencing throughput while lowering prices.
These qualities have enabled a variety of applications, including the study of the molecular causes of hereditary illnesses, combined with the technology's versatility.
The advancement of genomic technologies has accelerated the hunt for the genetic roots of human illnesses and given scientists the opportunity to address hitherto unanswerable issues about disease causation.
Conclusion
The next-generation sequencing (NGS) technology has advanced significantly over time. All this development has aided in the advancement of clinical disease, medicine development, and genome research. NGS kits have flourished and found applications in a wide range of fields within healthcare and clinical diagnostics.
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